This has been an interesting area of research for some time (see the reconstruction of the Sleeping Beauty transposon); it often provokes responses from various pseudoscientific religious fundamentalists. Here is a recent example, the reconstruction of an ancestral glucocorticoid receptor.
At Panda's Thumb, P.Z. Meyers (post 1, post2) and Jack Scanlon respond to various distortions of the science.
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